Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models (8 page pdf, M Cacciottolo, X Wang, I Driscoll, N Woodward, A Saffari, J Reyes, M L Serre, W Vizuete, C Sioutas, T E Morgan, M Gatz, H C Chui, S A Shumaker, S M Resnick, M A Espeland, C E Finch and J C Chen, Translational Psychiatry, Jan. 31, 2017)
Also discussed here: Air pollution may cause 21 percent of dementias worldwide, study suggests (The San Diego Union-Tribune, Feb. 1, 2017)
And here: Early Onset Familial AD (Gabrielle Strobel, ALZFORUM)
Today we review research based on longer term exposure by female mice to PM 2.5 and how this could affect older women exposed to traffic-related air pollution in their risks of having dementia. Results indicate that women in the late 60s and 70s are 92% more likely to develop dementia if they live in areas that exceed EPA’s standards for PM2.5. The increase in the elderly and the greater risk of dementia has resulted in an overall increase in this disease, despite the improvements in levels of PM 2.5 over the last decade or two, as well as in the increase of deaths from Alzheimer’s, the sixth leading cause of death nationwide.
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